Infigratinib靶向的FGFR3（成纤维细胞生长因子受体3）正是驱动ACH疾病发生的关键靶点，2月12日，BridgeBio公布Infigratinib在ACH中取得的首个具有统计学显著改善意义的3期顶线结果，公司计划下半年向FDA提交新药申请。
France (15 points) Three games played, three bonus-point victories banked and the title at their mercy. If they claim another four-try win at Murrayfield on Saturday week, they will secure the crown with a round to spare, setting up a rousing grand slam opportunity in Paris. Above all else, though, Les Bleus have illuminated this year’s championship with their pace and attacking grace, not least “King” Louis Bielle-Biarrey who has been spectacularly good. How many other sides in the world, aside from South Africa, can also interchange their second-row and midfield pairings without missing a beat? Or casually whistle up gifted youngsters such as Fabien Brau-Boirie, Émilien Gailleton and Gaël Dréan who all look instantly to the manner born. When you factor in the squad’s collective ability with and without the ball – to date France have scored the most tries, 18, and conceded the fewest, five – the future looks dazzlingly bright.
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